Buy U-48800 with safety with us.
U-48800 is a designer chemical similar to the opioid class, intended for chemical research and forensic examinations.U-48800 is produced on modern chemical equipment in compliance with all standards, which makes this chemical as clean and quality as possible.
U-47700 is a structural isomer of the earlier opioid AH-7921 and the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold. Upjohn looked for the key moieties which gave the greatest activity and posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active.
U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a single methylene spacer difference) and U-69,593, which share very similar structures.Although not used medically, the selective kappa ligands are used in research.
This Cerilliant product is part of the Centers for Disease Control and Prevention (CDC) Opioid CRM Kit including more than 40 CRMs to be used as part of CDC’s laboratory response to the opioid epidemic. The kits are provided free of charge to drug testing laboratories located in the United States.
Determination of plasma protein binding
As classical ultrafiltration may have the non‐specific binding as disadvantages compared to equilibrium dialysis,the used filtration membrane consisted of regenerated cellulose, which was shown to avoid this issue.Free fraction of U‐48800 represents unbound drug
and was calculated to be 0.078, which resulted in a PPB of 92%. Amongst other factors, for example ionization state, there is a high correlation between lipophilicity and PPB.28,29 It is expected that a PPB over 70% would have significant effects on the pharmacokinetics and pharmacodynamics such as lower clearance. However, this effect will depend on the elimination route and/or active transport into the hepatocytes,which were not part of this study. Therefore, further studies are encouraged.